![]() It is a rare finding that clinicians should be well conversant with, especially in Africa where sickle cell disease is common. Conclusion: HOE sign is a complication of chronic hemolysis usually seen in patients with thalassemia and sickle cell anemia. She improved and was discharged 16 days later. Microangiopathic hemolytic anemia occurs when the red cell membrane is damaged in circulation, leading to intravascular hemolysis and the appearance of. The child was then initiated on hydroxyurea, antibiotics, analgesics and intravenous fluids. Hemoglobin (Hb) electrophoresis confirmed sickle cell disease (SCD). Check the full list of possible causes and conditions now Talk to our Chatbot to narrow down your search. CT demonstrated right cerebral intraparenchymal hemorrhage, multiple high cerebral infarcts on the right and evidence of extra medullary hematopoiesis with a classical HOE sign. Chest Pain, Jaundice & Scleral Icterus Symptom Checker: Possible causes include Sickle Cell Anemia. Clinical findings revealed severe pallor of the conjunctivae and mild scleral icterus. Case Summary: We present a 9-year-old Ugandan girl who presented with an unexplained stroke that preceded an episode of acute headache, vomiting, followed by focal convulsions and altered consciousness. Hb electrophoresis confirmed the diagnosis of sickle cell anemia. For example, treatment of sickle cell anemia may include drinking plenty of water, avoiding triggers like stress and, in severe cases, blood transfusions. It is a sign of jaundice, which is a symptom of an underlying condition, often of the liver. ![]() ![]() Here, we present a 9-year-old Ugandan girl who presented with stroke in whom head CT demonstrated cerebral intraparenchymal hemorrhage and multiple infarcts on the left with HOE sign. Yellow eyes occur when the whites of the eye (sclera) turn yellow (called scleral icterus). Thalassemia major and sickle cell disease. ![]() A vaso-occlusive crisis occurs when the microcirculation is obstructed by sickled RBCs, causing ischemic injury to the organ. It is classically seen in children/adolescents with hemolytic anemias, in particular, The most common clinical manifestation of SCD is vaso-occlusive crisis. The hair-on-end (HOE) sign is a rare finding seen in the diploic space on skull radiographs, computed tomography (CT) and magnetic resonance imaging (MRI) with the appearance of long, thin vertical striations of calcified spicules perpendicular to the bone surface that looks like hair standing on end. Examination revealed an asthenic, pale boy with scleral icterus. ![]()
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